UConn defeated Duke 37-34 in Week 11 of the 2025 season in a closely contested matchup. The Huskies led 20-17 at halftime before Duke mounted a second-half comeback, but UConn's fourth-quarter execution proved decisive.

Joe Fagnano led UConn's passing attack with 311 yards, while Camryn Edwards rushed for 51 yards and John Neider hauled in 9 receptions. The game featured dramatic momentum swings, with 28 lead changes and a maximum win probability swing of 43.83 percent, reflecting the competitive nature of the contest.

Duke's offense, led by quarterback D. Mensah, scored touchdowns in both the second and third quarters to keep pace with the Huskies. However, critical fourth-quarter plays decided the outcome. A pivotal 26-yard rush by A. Honig and a crucial sack-fumble recovery by UConn's T. Jones with 27 seconds remaining sealed the victory.

UConn covered the 8-point spread, and the combined 71 points exceeded the over-under of 63.0. The teams combined for an exciting display of offensive football in a game that came down to final-minute execution.